Applying ecological and evolutionary theory to cancer: a long and winding road
Frédéric Thomas
(1)
,
Daniel Fisher
(2)
,
Philippe Fort
(3)
,
Jean-Pierre Marie
(4)
,
Simon Daoust
(1)
,
Benjamin Roche
(5)
,
Christoph Grunau
(6)
,
Celine Cosseau
(6)
,
Guillaume Mitta
(6)
,
Stephen Baghdiguian
(7)
,
François Rousset
(7)
,
Patrice Lassus
(2)
,
Eric Assenat
(8)
,
Damien Grégoire
(2)
,
Dorothée Missé
(1)
,
Alexander Lorz
(9, 10)
,
Frédérique Billy
(9, 10)
,
William Vainchenker
(11)
,
François Delhommeau
(12)
,
Serge Koscielny
(13)
,
Raphael Itzykson
(13)
,
Ruoping Tang
(4)
,
Fanny Fava
(4)
,
Annabelle Ballesta
(14)
,
Thomas Lepoutre
(15, 16)
,
Liliane Krasinska
(3)
,
Vjekoslav Dulic
(3)
,
Peggy Raynaud
(3)
,
Philippe Blache
(17)
,
Corinne Quittau-Prévostel
(3)
,
Emmanuel Vignal
(3)
,
Hélène Trauchessec
(2)
,
Benoît Perthame
(14)
,
Jean Clairambault
(9, 10)
,
Urszula Hibner
(2)
,
Vitaly Volpert
(15)
,
Eric Solary
(13, 18)
,
Michael E. Hochberg
(7, 19, 20)
1
MIVEGEC -
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 IGMM - Institut de Génétique Moléculaire de Montpellier
3 CRBM - Centre de recherche en Biologie Cellulaire
4 UPMC - Université Pierre et Marie Curie - Paris 6
5 CREAD - Centre de Recherche sur l'Education, les apprentissages et la didactique
6 2EI - Ecologie et évolution des interactions [2011-2014]
7 UMR ISEM - Institut des Sciences de l'Evolution de Montpellier
8 Service Médico-Chirurgical des Maladies de l'Appareil Digestif et de Transplantation Hépatique
9 LJLL - Laboratoire Jacques-Louis Lions
10 BANG - Nonlinear Analysis for Biology and Geophysical flows
11 UPD5 - Université Paris Descartes - Paris 5
12 CIC Saint-Antoine
13 Hématopoïèse normale et pathologique
14 DMA - Département de Mathématiques et Applications - ENS Paris
15 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
16 ICJ - Institut Camille Jordan
17 LPL - Laboratoire Parole et Langage
18 LNC - Lipides - Nutrition - Cancer (U866)
19 NCEAS - National Center for Ecological Analysis and Synthesis
20 Santa Fe Institute
2 IGMM - Institut de Génétique Moléculaire de Montpellier
3 CRBM - Centre de recherche en Biologie Cellulaire
4 UPMC - Université Pierre et Marie Curie - Paris 6
5 CREAD - Centre de Recherche sur l'Education, les apprentissages et la didactique
6 2EI - Ecologie et évolution des interactions [2011-2014]
7 UMR ISEM - Institut des Sciences de l'Evolution de Montpellier
8 Service Médico-Chirurgical des Maladies de l'Appareil Digestif et de Transplantation Hépatique
9 LJLL - Laboratoire Jacques-Louis Lions
10 BANG - Nonlinear Analysis for Biology and Geophysical flows
11 UPD5 - Université Paris Descartes - Paris 5
12 CIC Saint-Antoine
13 Hématopoïèse normale et pathologique
14 DMA - Département de Mathématiques et Applications - ENS Paris
15 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
16 ICJ - Institut Camille Jordan
17 LPL - Laboratoire Parole et Langage
18 LNC - Lipides - Nutrition - Cancer (U866)
19 NCEAS - National Center for Ecological Analysis and Synthesis
20 Santa Fe Institute
Frédéric Thomas
- Function : Author
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Philippe Fort
- Function : Author
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Christoph Grunau
- Function : Author
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- IdRef : 17660832X
Celine Cosseau
- Function : Author
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Guillaume Mitta
- Function : Author
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Stephen Baghdiguian
- Function : Author
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François Rousset
- Function : Author
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Patrice Lassus
- Function : Author
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Eric Assenat
- Function : Author
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Damien Grégoire
- Function : Author
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Dorothée Missé
- Function : Author
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William Vainchenker
- Function : Author
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Raphael Itzykson
- Function : Author
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Thomas Lepoutre
- Function : Author
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Vjekoslav Dulic
- Function : Author
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Emmanuel Vignal
- Function : Author
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- IdHAL : emmanuel-vignal
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Benoît Perthame
- Function : Author
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Jean Clairambault
- Function : Author
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Vitaly Volpert
- Function : Author
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Eric Solary
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Michael E. Hochberg
- Function : Author
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- IdRef : 084321288
Abstract
Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
Origin : Publisher files allowed on an open archive
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